Precision bioactives — a new category

Healthy aging starts in the gut.So do we.

Trilliome is a healthcare company, built on the biology of the gut — pioneering a new class of precision bioactives: plant-derived actives that act with species-level precision, at milligrams, not grams, and formulate into any format. The science of healthspan — supplied to the brands building its next era, and only beginning to show what it can do.

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Signed LOIs — incl. a top-4 global ingredient company (~80–170 kg first-year)
EPO
Favourable Search Opinion on the cognitive indication
2025 industry awards — EIT Food, ARDD, Probiota
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Advisory board — Nestlé HS, dsm-firmenich, Bayer, H&H
The problem

Healthspan brands face an impossible trade-off.

Every brand wants to build the next generation of healthy-aging products — with claims they can actually stand behind. The ingredient shelf won't let them.

01

The actives with real biology are the hardest to work with

The microbes most tied to cognitive and metabolic health are strict anaerobes that die in manufacturing. Live probiotics need cold chains. Conventional prebiotics work only at 5–10 gram doses and feed bacteria indiscriminately.

02

The actives that are easy to formulate are commodities

Differentiation-free, claim-free, margin-thin.

03

So brands choose

Efficacy or formulability, science or simplicity. And the healthspan claim that would actually move the category stays out of reach.

You shouldn't have to choose.

The solution

A new category: precision bioactives.

Precision bioactives resolve the trade-off. They carry the biology — and they're built to formulate.

01

Species- & network-level precision

Targeted modulation of the specific biology of aging, not a broad-spectrum guess.

02

Milligrams, not grams

Active at small, precise doses — so they fit premium, compact formats instead of bulking them out.

03

Shelf-stable, plant-derived

Small molecules, not live cells. No cold chain.

04

Any format

Capsules, sticks, beverages, bars, foods, topicals.

05

Clean by design

Green, food-grade extraction from upcycled agricultural side-streams — no harsh solvents.

06

A claim you can substantiate

A clear mechanism, a Self-Affirmed GRAS pathway, and an evidence program that deepens over time.

One platform, the domains that define healthspan — cognition, metabolic health, and women's health — connected by a single biological thread: the modulation of chronic inflammation, the common denominator of aging.

Chronic inflammation Cognition Metabolic health Women's health
The platform

We don't make an ingredient. We make a category.

At Trilliome's core is Teroka — a closed loop between a wetlab engine that generates microbiome-response data and a computational engine (data science and machine learning) that learns from it — teaching us how to steer the gut ecosystem with high specificity, through bioactives and their combinations. We don't search for one lucky compound; we model the ecosystem and modulate it at scale.

TRI-01 and TRI-04 are the first two outputs. The platform is repeatable, it compounds, and it's the company — ingredients are the beginning, not the boundary.
generates response data designs the next experiments Wetlab engine turns biology into data Computational engine data science · ML PRECISION BIOACTIVES TRI-01 · TRI-04

Teroka — two engines, tightly coupled, each making the other smarter.

The portfolio

The first two outputs of a repeatable engine.

TRI-01

Precision gut-brain activator

Shelf-stable · milligram-scale · any format

A shelf-stable active that selectively induces a named four-species consortium of butyrate-producing gut bacteria — gut-health claims at launch, gut-brain as the evidence builds.

TRI-01
TRI-04

Low-MW prebiotic fibre

Water-soluble · metabolic-health path · lean GRAS

A water-soluble prebiotic fibre that supports the gut's butyrate-producing bacteria, with a metabolic-health (GLP-1 axis) claim path under study.

TRI-04
Insights

Defining the category, in the open.

Opinion and thought leadership from our scientists — on the gut-brain axis, precision modulation of the microbiome, butyrate biology, and what "evidence" should mean for functional ingredients.

Read our insights